Addiction is a primary, chronic disease of
brain reward, motivation, memory and related
circuitry. Dysfunction in these circuits leads to
characteristic biological, psychological, social
and spiritual manifestations. This is reflected in an
individual pathologically pursuing reward and/
or relief by substance use and other behaviors.
Addiction is characterized by inability to
consistently abstain, impairment in behavioral
control, craving, diminished recognition of
significant problems with one’s behaviors and
interpersonal relationships, and a dysfunctional
emotional response. Like other chronic diseases,
addiction often involves cycles of relapse and
remission. Without treatment or engagement in
recovery activities, addiction is progressive and
can result in disability or premature death.